New antimicrobial agents require careful assessment to determine wheth
er they possess the appropriate properties for clinical use. Many new
compounds of value in the prophylaxis and therapy of infections have b
een included in the current armamentarium. Close monitoring to identif
y possible adverse effects of new agents is essential. Alternative use
s of older agents also expands therapeutic opportunities in the combat
against infectious diseases. Inappropriate use of antimicrobial agent
s contributes to the worldwide problem of increasing bacterial resista
nce. The dramatic spread of such bacterial strains is partially respon
sible for the rising costs of infectious diseases. A rational and stri
ct antibiotic policy is thus of great importance for the optimal use o
f these agents.