DEVELOPMENT OF A HIGH-DOSE TECHNETIUM TC99M LABELED SULFUR COLLOID METERED DOSE INHALATION AEROSOL

Authors
GADDIPATI N GRAZIOSI M ELLWAY K GANESAN M
Citation
N. Gaddipati et al., DEVELOPMENT OF A HIGH-DOSE TECHNETIUM TC99M LABELED SULFUR COLLOID METERED DOSE INHALATION AEROSOL, Drug development and industrial pharmacy, 19(10), 1993, pp. 1159-1168
Citations number
18
Journal title
Drug development and industrial pharmacy → ACNP
ISSN journal
03639045
Volume
19
Issue
10
Year of publication
1993
Pages
1159 - 1168
Database
ISI
SICI code
0363-9045(1993)19:10<1159:DOAHTT>2.0.ZU;2-G
Abstract
Radiolabeled Technetium sulfur colloid metered dose inhalation aerosol (MDI) suitable to evaluate pulmonary deposition from inhalation devic es has been developed by using a lyophilization process to prepare the radiolabeled material for aerosolization. The reproducibility of the manufacturing process was demonstrated by characterizing the aerosol p erformance with respect to dose delivery, particle size, and valve del ivery.