INVESTIGATION OF THE GLUCOSE PROPYLAMINE REACTION BY HPLC

The reaction of glucose with propylamine has been investigated by HPLC . The main products detectable by UV absorption were hydroxy-2-(hydrox y-methyl)-5-methyl-3(2H)-furanone (4), 2,3-dihydro-3,5-dihydroxy-6-met hyl-4H-pyran-4-one (5), 5-hydroxy-methyl-2-furancarbaldehyde, -trihydr oxypro-pyl)-l-propyl-2-pyrrolecarbaldehyde (6a) and 5-hydroxymethyl-1- propyl-2-pyrrolecarbaldehyde (7a). The yield of products was highly de pendent on the reaction conditions. In neutral solution mainly 4 and 5 were formed, whereas at pH 5.0 pyrroles dominated.