5'-NOR-ANHYDROVINBLASTINE (NAVELBINE(R)) HAS AN ANTI-INVASIVE EFFECT ON MO4 MOUSE FIBROSARCOMA CELLS-INVITRO AND INVIVO

Authors
VANDENBERGE D BRUYNEEL E DISTELMANS W VANBELLE S KRIKONIAN A BREILLOUT F STORME G
Citation
D. Vandenberge et al., 5'-NOR-ANHYDROVINBLASTINE (NAVELBINE(R)) HAS AN ANTI-INVASIVE EFFECT ON MO4 MOUSE FIBROSARCOMA CELLS-INVITRO AND INVIVO, Anticancer research, 13(1), 1993, pp. 273-278
Citations number
15
Journal title
Anticancer research → ACNP
ISSN journal
02507005
Volume
13
Issue
1
Year of publication
1993
Pages
273 - 278
Database
ISI
SICI code
0250-7005(1993)13:1<273:5(HAAE>2.0.ZU;2-X
Abstract
5'-nor-anhydrovinblastine (Navelbine(R)) is a hemisynthetic Vinca alka loid for which a selectivity for mitotic microtubules has been demonst rated. In previous studies, we have demonstrated an anti-invasive effe ct of other Vinca alkaloids. Here the results of in vitro and in vivo assays concerning the effect of 5'-nor-anhydrovinblastine on growth an d invasion of M04 cells are presented. It is demonstrated that at cyto static concentrations, 5'-nor-anhydrovinblastine also has an anti-inva sive effect.