THEORETICAL ASPECTS OF CHIRAL SEPARATION IN CAPILLARY ELECTROPHORESIS.3. APPLICATION TO BETA-BLOCKERS

Enantiomers of the beta-blockers propranolol, atenolol, metoprolol, an d oxprenolol have been separated by the addition of methyl-beta-cyclod extrin (MeBCD) to the operating buffer. There is an optimum concentrat ion of MeBCD for separation for each of the beta-blockers, the magnitu de of which could be ranked by the use of a mathematical model and log P data -an indication of the hydrophobicity of the molecule.