Sac. Wren et Rc. Rowe, THEORETICAL ASPECTS OF CHIRAL SEPARATION IN CAPILLARY ELECTROPHORESIS.3. APPLICATION TO BETA-BLOCKERS, Journal of chromatography, 635(1), 1993, pp. 113-118
Enantiomers of the beta-blockers propranolol, atenolol, metoprolol, an
d oxprenolol have been separated by the addition of methyl-beta-cyclod
extrin (MeBCD) to the operating buffer. There is an optimum concentrat
ion of MeBCD for separation for each of the beta-blockers, the magnitu
de of which could be ranked by the use of a mathematical model and log
P data -an indication of the hydrophobicity of the molecule.