INVIVO CONTROL OF TUMOR-GROWTH WITH THE ASSOCIATION OF IONIDAMINE WITH RADIATION AND OR HYPERTHERMIA

The effect of lonidamine (LND) in association with fractionated doses of radiation and/or hyperthermia on tumor growth has been evaluated. T he results may be summarized as follows: (i) the fractionation of the radiation dose, in spite of the higher dose delivered (20 Gy) does not increase tumor growth delay when compared to that obtained with a sin gle irradiation treatment. A similar behaviour was also found when the fractionated irradiation was associated with LND. (ii) Hyperthermia i s less effective than radiation in controlling tumor growth, but its e ffect is potentiated by LND although to a lesser extent that with radi ation. (iii) LND delivered together with hyperthermia and radiation ar rests tumor growth, and leads to the disappearance of the tumor in 75% of mice. The possible mechanisms underlying these effects are discuss ed.