SERUM LEVELS OF 2', 5 OLIGOADENYLATE SYNTHETASE DURING INTERFERON THERAPY IN PATIENTS WITH B-CELL CHRONIC LYMPHOCYTIC-LEUKEMIA

We assayed 2', 5 oligoadenylate synthetase (2'5-AS) activity in the se rum of eight patients with B-cell chronic lymphocytic leukemia (B-CLL) who were undergoing therapy with alpha interferon (IFN). Mean pretrea tment levels of 2'5-AS were normal, but upon treatment the levels rose to higher than normal values. Moreover, the degree of enzyme inductio n in serum was significantly higher in CLL responders (P < 0.003) wher eas no difference was found in non-responders. The lack of serum 2'5-A S induction in nonresponder patients might be related to unresponsiven ess to treatment with IFN. These results seem to show that the measure ment of serum levels of 2'5-AS activity may be a useful tool in monito ring IFN treatment.