MULTIPLE CEREBRAL ANEURYSMS IN PATIENTS WITH SICKLE-CELL DISEASE

Patients with sickle cell disease appear to have a high incidence of c erebral aneurysm. These aneurysms are not associated with the usual ri sk factors of hypertension, renal disease, or connective tissue diseas e. We present two recent cases of patients with sickle cell disease an d multiple cerebral aneurysms, review the literature on the associatio n between sickle cell disease and cerebral aneurysms, and discuss a me chanism by which sickle cell disease may lead to the formation of cere bral aneurysms.