PREVENTION OF RESPIRATORY-FAILURE AFTER HYDROCHLORIC-ACID ASPIRATION BY INTRATRACHEAL SURFACTANT INSTILLATION IN RATS

Citation
Ep. Eijking et al., PREVENTION OF RESPIRATORY-FAILURE AFTER HYDROCHLORIC-ACID ASPIRATION BY INTRATRACHEAL SURFACTANT INSTILLATION IN RATS, Anesthesia and analgesia, 76(3), 1993, pp. 472-472
Citations number
23
Journal title
ISSN journal
00032999
Volume
76
Issue
3
Year of publication
1993
Pages
472 - 472
Database
ISI
SICI code
0003-2999(1993)76:3<472:PORAHA>2.0.ZU;2-Y
Abstract
Because the surfactant system probably is involved in the pathophysiol ogy of respiratory failure caused by hydrochloric acid (HCl) aspiratio n, we investigated the effects of different ventilation strategies and intratracheal surfactant instillation at different time intervals on the course of pulmonary gas exchange after HCl aspiration in rats. In this study rats were anesthetized and mechanically ventilated via a tr acheostomy. Respiratory failure was induced by intratracheal instillat ion of 3 mL/kg 0.1 N HCl. Animals (n = 49) were divided into nine grou ps: Groups 1 and 2 through 9 were ventilated with peak airway pressure /positive end-expiratory pressure of 14/2 and 26/6 cm H2O, respectivel y; Groups 3 and 4 received surfactant (200 mg/kg) intratracheally, 1 a nd 10 min after HCl aspiration; Groups 5 and 6 received saline, 1 and 10 min after HCl aspiration; Groups 7 and 8 received surfactant, 60 an d 90 min after HCl aspiration; Group 9 received saline instead of HCl. Gas exchange deteriorated in Groups 1, 2, 5, 6, 7, and 8, whereas res piratory failure could be prevented in Groups 3 and 4. After deteriora tion of gas exchange, surfactant treatment prevented further decrease of PaO2 values in Group 7, whereas no effect on gas exchange was obser ved in Group 8; intratracheal instillation of saline had no effect on gas exchange (Group 9). These results suggest that surfactant should b e given as early as possible after aspiration of gastric contents to p revent development of respiratory failure.