Because the left upper lobe bronchus overlies the left pulmonary arter
y (PA), T2-3 lesions, N0-1 disease, or rarely inflammation may involve
this vessel, necessitating lobectomy with partial PA resection or pne
umonectomy with sacrifice of the lower lobe. In 486 operations perform
ed for left upper lobe lesions between 1966 and 1992 (wedge, 111; segm
entectomy, 131; lobectomy, 155; pneumonectomy, 89), isolated PA encroa
chment was caused by bronchogenic carcinoma (32), invasive aspergillos
is (2), or organized pneumonitis (1) and occurred in 9% (32/360) of ma
lignant left upper lobe tumors and 2% (3/126) of benign lesions. Initi
ally (1966 through 1979), PA involvement was the indication for 30% (1
8/60) of left pneumonectomies. Later (1980 through 1990), tangential r
esection of the PA was attempted in 11, 5 ending up with pneumonectomy
. Overall, 35 of 244 patients undergoing major left upper lobe resecti
on (lobectomy or pneumonectomy) had PA encroachment. Recently, we have
performed, selectively in patients with restricted lung function, six
left upper lobectomies with sleeve resection of the PA. Paneled saphe
nous vein interposition was used (3) or 18-mm polytetrafluoroethylene
tube prostheses (3). All patients survived, 1 later requiring completi
on pneumonectomy for bronchostenosis after wedge bronchoplasty. Two ha
ve since died of metastases or pulmonary insufficiency; the remainder
(average follow-up, 17 months) are asymptomatic with lower lobe functi
on in 3 confirmed by differential ventilation-perfusion scans and pulm
onary angiography.