A BREAST-OVARIAN CANCER SUSCEPTIBILITY GENE MAPS TO CHROMOSOME-17Q21

Authors
FEUNTEUN J NAROD SA LYNCH HT WATSON P CONWAY T LYNCH J PARBOOSINGH J OCONNELL P WHITE R LENOIR GM
Citation
J. Feunteun et al., A BREAST-OVARIAN CANCER SUSCEPTIBILITY GENE MAPS TO CHROMOSOME-17Q21, American journal of human genetics, 52(4), 1993, pp. 736-742
Citations number
14
Journal title
American journal of human genetics → ACNP
ISSN journal
00029297
Volume
52
Issue
4
Year of publication
1993
Pages
736 - 742
Database
ISI
SICI code
0002-9297(1993)52:4<736:ABCSGM>2.0.ZU;2-J
Abstract
Nineteen North American Caucasian families that contain a minimum of f our confirmed cases of breast or ovarian cancer have been studied. Fou r polymorphisms (cLB17.1, D17S579, D17S588, and D17S74), which span a region of approximately 15 cM on chromosome 17q12, were typed. Our dat a confirm the location of a dominant gene conferring susceptibility to breast and ovarian cancer (maximum lod = 9.78) and suggest that the b reast-ovarian cancer syndrome is genetically heterogeneous. Two recomb inants in one large family suggest that the breast-ovarian cancer locu s lies between D17S588 and D17S579.