LINKAGE ANALYSIS OF 19 FRENCH BREAST-CANCER FAMILIES, WITH 5 CHROMOSOME-17Q MARKERS

Authors
MAZOYER S LALLE P NAROD SA BIGNON YJ COURJAL F JAMOT B DUTRILLAUX B STOPPALYONNET D SOBOL H
Citation
S. Mazoyer et al., LINKAGE ANALYSIS OF 19 FRENCH BREAST-CANCER FAMILIES, WITH 5 CHROMOSOME-17Q MARKERS, American journal of human genetics, 52(4), 1993, pp. 754-760
Citations number
15
Journal title
American journal of human genetics → ACNP
ISSN journal
00029297
Volume
52
Issue
4
Year of publication
1993
Pages
754 - 760
Database
ISI
SICI code
0002-9297(1993)52:4<754:LAO1FB>2.0.ZU;2-#
Abstract
Nineteen French breast and breast-ovarian cancer families were tested for linkage with five chromosome 17q markers. The five breast-ovarian cancer families as a group give positive evidence for linkage, whereas the 14 breast cancer-only families do not. Heterogeneity of linkage o f breast and breast-ovarian cancers is significant in France and suppo rts the existence of more than one susceptibility gene.