GENETIC-HETEROGENEITY AND LOCALIZATION OF A FAMILIAL BREAST-OVARIAN CANCER GENE ON CHROMOSOME 17Q12-Q21

Authors
SMITH SA EASTON DF FORD D PETO J ANDERSON K AVERILL D STRATTON M PONDER M PYE C PONDER BAJ
Citation
Sa. Smith et al., GENETIC-HETEROGENEITY AND LOCALIZATION OF A FAMILIAL BREAST-OVARIAN CANCER GENE ON CHROMOSOME 17Q12-Q21, American journal of human genetics, 52(4), 1993, pp. 767-776
Citations number
9
Journal title
American journal of human genetics → ACNP
ISSN journal
00029297
Volume
52
Issue
4
Year of publication
1993
Pages
767 - 776
Database
ISI
SICI code
0002-9297(1993)52:4<767:GALOAF>2.0.ZU;2-#
Abstract
In a study of 31 breast cancer families and 12 breast-ovarian cancer f amilies, we have obtained clear evidence of linkage to markers on chro mosome 17q in the families with ovarian cancer (maximum lod score 3.34 at theta = .04) but only weak evidence in those without ovarian cance r. Recombinant events indicate that the gene lies between D17S588 and D17S250.