LOCAL CEREBRAL BLOOD-FLOW IN RATS WITH CONGENITAL HYDROCEPHALUS

Local cerebral blood flow (LCBF) has been measured by [C-14]iodoantipy rine quantitative autoradiography in H-Tx rats with inherited congenit al hydrocephalus at 10, 21, and 30 days after birth. LCBF at 10 days w as uniformly low in all ten brain regions studied and not significantl y different between hydrocephalic and age-matched control rats. By 21 days LCBF had increased significantly in control rats. LCBF was signif icantly lower (<69%) in the hydrocephalics in all cortical regions and in the inferior colliculus LCBF at both 21 and 30 days. The cerebella r cortex, pons, and caudate were not significantly affected. At 30 day s LCBF ranged from 55 to 115 ml 100 g-1 min-1 for hydrocephalics and f rom 100 to 183 ml 100 g-1 min-1 for controls.