SIMULATION OF THE DIFFERENTIAL ADHESION DRIVEN REARRANGEMENT OF BIOLOGICAL CELLS

We show that differential adhesion with fluctuations is sufficient to explain a wide variety of cell rearrangement, by using the extended la rge-Q Potts model with differential adhesivity to simulate different b iological phenomena. Different values of relative surface energies cor respond to different biological cases, including complete and partial cell sorting, checkerboard, position reversal, and dispersal. We exami ne the convergence and temperature dependence of the simulation and di stinguish spontaneous, neutral, and activated processes by performing simulations at different temperatures. We discuss the biological and p hysical implications of our quantitative results.