The corpus callosum is the major axonal commissure of the brain, conne
cting the two cerebral hemispheres and providing communication between
the cortical and subcortical neurons. With MR imaging in the sagittal
plane, the corpus callosum can be depicted in great detail. We review
the normal anatomy, development, and process of myelination of the co
rpus callosum. The MR features of various pathologic conditions involv
ing the corpus callosum are described. Finally, we discuss the evolvin
g role of MR imaging in neuropsychiatric diseases with respect to the
corpus callosum.