SOMATIC MUTATION AND MEMORY

Authors
BEREK C
Citation
C. Berek, SOMATIC MUTATION AND MEMORY, Current opinion in immunology, 5(2), 1993, pp. 218-222
Citations number
35
Categorie Soggetti
Immunology
Journal title
Current opinion in immunology → ACNP
ISSN journal
09527915
Volume
5
Issue
2
Year of publication
1993
Pages
218 - 222
Database
ISI
SICI code
0952-7915(1993)5:2<218:SMAM>2.0.ZU;2-I
Abstract
The germinal center plays a crucial role in the development of the mem ory B cell. The repertoire of the antigen-specific B cell is shaped in this microenvironment. Self-specific B cells escaping normal regulati on may develop into high affinity pathogenic Ig-producing cells.