POSTOPERATIVE ANALGESIA WITH TRAMADOL - A CONTROLLED-STUDY COMPARED WITH AN ANALGESIC COMBINATION

The analgesic action of tramadol in the post-operative period was comp ared with that of an analgesic combination (Nisidin) in a sample of 60 patients (31 male, 29 female) aged between 20 and 70 years undergoing surgical operations on the abdomen involving opening of the peritoneu m. The study was carried out according to a controlled and randomized experimental design. Tramadol in 100 mg/2ml vials and Nisidin in 2ml v ials were administered parenterally at a dosage of three vials a day d uring the first three days of the post-operative period. The analgesic action of tramadol was shown to be more effective than that of Nisidi n both after the first dose and during the three days of observation ( p < 0.01). Local and general safety were good in both groups, and resp iratory and heart rates did not undergo clinically significant modific ations. In conclusion, tramadol proves to be particularly indicated in the treatment of post-operative pain, given that it has analgesic act ion combined with good local and general safety.