CLINICAL ANALYSIS OF 125 PATIENTS WITH THE LUPUS ANTICOAGULANT

A retrospective analysis of 125 consecutive lupus anticoagulant (LA) p ositive patients and 125 age, sex matched lupus anticoagulant negative controls is reported with the aims of defining further the clinical s pectrum of disease, determining at-risk subgroups and management strat egies. There was no significant difference in the incidence or pattern of complications in those with systemic lupus erythematosus (SLE) and related disorders, and those without SLE. Venous thromboembolism, imm une thrombocytopenia, foetal loss, depression and hypertension were st atistically more common in the LA group than in the control group. In contrast to previous reports, children aged ten years or less with the LA developed significantly more complications than controls. Patients with the LA secondary to drugs also developed complications, a findin g which is also at variance with previous reports. There was a signifi cant difference in the outcome of arterial disease (p < 0.04) and veno us thromboembolism (p < 0.001) when long term anticoagulation was part of the treatment regimen.