Citation
D. Hesk et al., SYNTHESIS OF TRITIUM LABELED MOMETASONE FUROATE, Journal of labelled compounds & radiopharmaceuticals, 33(5), 1993, pp. 439-442
Citations number
2
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy
Journal title
ISSN journal
03624803
Volume
33
Issue
5
Year of publication
1993
Pages
439 - 442
Database
ISI
SICI code
0362-4803(1993)33:5<439:SOTLMF>2.0.ZU;2-A
Abstract
H-3-mometasone furoate was synthesized by a six step procedure. The la
bel was introduced via the reduction and re-oxidation of the 1,2 doubl
e bond in the A ring. The remaining 4 steps were accomplished with on
overall radiochemical yield of 28%. Analysis by H-3 nmr indicated that
most of the label (almost-equal-to 95%) was located in the 2-position
and the remainder in the 1-position.