EFFECT OF DIMETICONE ON THE PHARMACOKINETICS AND PHARMACODYNAMICS OF ETHYL BISCOUMACETATE

The influence of dimeticone (Gel de Polysilane Midy(R)) on the pharmac okinetics and pharmacodynamics of oral ethyl biscoumacetate was studie d in 6 healthy volunteers in a randomised single dose, two-way cross-o ver study. Each volunteer received at one week interval a single dose (300 mg) of ethyl biscoumacetate, either alone or with dimeticone. Eth yl biscoumacetate levels were measured in plasma for 24 hours. Pharmac odynamic parameters were measured for 96 hours. Ethyl biscoumacetate p eak concentration was significantly higher when administered with dime ticone (40.3 +/- 25.3 mg/l vs 31.0 +/- 25.7 mg/l ; p = 0.031), without significant change in the area under curve. Other pharmacokinetic and pharmacodynamic parameters did not differ significantly. The slight i ncrease of the ethyl biscoumacetate bioavailability with dimeticone in repeated dosing might have pharmacodynamic consequence ; a clinical t rial should address this question.