ACUTE TOXICITY OF ZIDOVUDINE - ANALYSIS OF 43 OVERDOSAGES

Authors
MAIGNEN F MEGLIO S BIDAULT I CASTOT A
Citation
F. Maignen et al., ACUTE TOXICITY OF ZIDOVUDINE - ANALYSIS OF 43 OVERDOSAGES, Therapie, 48(2), 1993, pp. 129-131
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Therapie → ACNP
ISSN journal
00405957
Volume
48
Issue
2
Year of publication
1993
Pages
129 - 131
Database
ISI
SICI code
0040-5957(1993)48:2<129:ATOZ-A>2.0.ZU;2-9
Abstract
13 cases of zidovudine overdosage have been previously published ; 30 have been notified to Paris Control Poison Centre up to January 1991. This analysis shows that acute toxicity appears unfrequent and mild wh en ingested dose is lower than 25 gr. However it appears from this ser ies that an haematologic monitoring is needed because of the risk of m yelosuppression.