HISTOCHEMICAL AND IMMUNOCYTOCHEMICAL STUDY OF UBIQUITINATED NEURONAL INCLUSIONS IN AMYOTROPHIC-LATERAL-SCLEROSIS

Authors
MATHER K MARTIN JE SWASH M VOWLES G BROWN A LEIGH PN
Citation
K. Mather et al., HISTOCHEMICAL AND IMMUNOCYTOCHEMICAL STUDY OF UBIQUITINATED NEURONAL INCLUSIONS IN AMYOTROPHIC-LATERAL-SCLEROSIS, Neuropathology and applied neurobiology, 19(2), 1993, pp. 141-145
Citations number
24
Categorie Soggetti
Neurosciences,Pathology
Journal title
Neuropathology and applied neurobiology → ACNP
ISSN journal
03051846
Volume
19
Issue
2
Year of publication
1993
Pages
141 - 145
Database
ISI
SICI code
0305-1846(1993)19:2<141:HAISOU>2.0.ZU;2-8
Abstract
Ubiquinated cytoplasmic inclusions are a characteristic feature of the anterior horn cell pathology of amyotrophic lateral sclerosis. The un derlying abnormality leading to the production of these inclusions in this neurodegenerative motor system disease is unknown. Despite the ap plication of a wide range of histochemical and immunocytochemical tech niques we have been unable to identify a core constituent protein in t hese intraneuronal inclusions. A novel approach to this problem is req uired.