MULTIFOCAL MOTOR NEUROPATHY PRESENTING AS OPHTHALMOPLEGIA

A 45-year-old man developed ophthalmoplegia and subsequently multiple cranial nerve palsies in association with bibrachial paresis. Investig ations revealed evidence of conduction block occurring at a very proxi mal location (i.e., the spinal roots) and seemingly sparing sensory fi bers. Other causes were ruled out and a diagnosis of multifocal motor neuropathy with conduction block (MMN) was suggested. The patient resp onded to cyclophosphamide. Differentiating features between MMN and ch ronic inflammatory demyelinating polyradioneuropathy (CIDP) are discus sed. This case demonstrates that MMN may rarely present with ophthalmo paresis and also demonstrates that features of MMN and CIDP may overla p. (C) 1997 John Wiley & Sons, Inc.