Rs. Izzo et al., NEUTROPHIL-ACTIVATING PEPTIDE (INTERLEUKIN-8) IN COLONIC MUCOSA FROM PATIENTS WITH CROHNS-DISEASE, Scandinavian journal of gastroenterology, 28(4), 1993, pp. 296-300
We considered the role of two neutrophil chemotactic agents (interleuk
in-8 and leukotriene B4 an of myeloperoxidase (a neutrophil-associated
enzyme) in the pathologic condition of Crohn's disease (CD). Serial b
iopsy samples were taken at different sites in the colon, washed in 0.
02 M phosphate-saline buffer, homogenized, and then sonicated. Interle
ukin-8 levels were significantly increased throughout the colonic muco
sa (>300 pg/mg protein) in patients with CD compared with control grou
ps (<40 pg/mg protein) (p less-than-or-equal-to 0.01). A two- to six-f
old increase in leukotriene B4 was also found in CD, whereas mucosal l
evels of myeloperoxidase were unchanged compared with control subjects
. This study demonstrates that interleukin-8 and leukotriene B4 may ha
ve an immunologic role in the pathologic condition of CD.