MALIGNANT FIBROUS HISTIOCYTOMA OF THE SOFT-TISSUES OF THE TRUNK AND EXTREMITIES

Malignant fibrous histiocytoma (MFH) is the most commonly diagnosed so ft-tissue sarcoma. Of 408 retrospectively reviewed patients with MFH, 220 patients had primary, localized, previously untreated tumors invol ving the extremities or limb girdles. Univariate statistical analysis of results revealed five prognostic factors that were significantly re lated to poor outcome: old age, deeply seated lesions, surgical grade, large size, and marginal or intralesional surgery. Multivariate analy sis revealed only three factors that were significantly related to poo r prognosis: old age, deeply seated lesions, and inadequate surgery.