SELECTIVE-INHIBITION OF INVITRO-CELL GROWTH BY THE ANTITUMOR DRUG UKRAIN

Authors
HOHENWARTER O STRUTZENBERGER K KATINGER H LIEPINS A NOWICKY JW
Citation
O. Hohenwarter et al., SELECTIVE-INHIBITION OF INVITRO-CELL GROWTH BY THE ANTITUMOR DRUG UKRAIN, Drugs under experimental and clinical research, 18, 1992, pp. 1-4
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Drugs under experimental and clinical research → ACNP
ISSN journal
03786501
Volume
18
Year of publication
1992
Supplement
S
Pages
1 - 4
Database
ISI
SICI code
0378-6501(1992)18:<1:SOIGBT>2.0.ZU;2-B
Abstract
The inhibitory effect of Ukrain on malignant cells and on normal cells , in vitro, has been compared. To obtain a 50% inhibition of cell grow th, a tenfold concentration had to be used with normal endothelial cel ls compared to a human osteosarcoma cell line. Hybrids of the two cell types showed nearly the same sensitivity as normal cells. A laser sca nning microscope showed a high uptake of Ukrain in malignant cells, wh ile the content in normal cells under the same experimental conditions was substantially lower.