THE EFFECTS OF THIOPHOSPHORIC ACID (UKRAIN) ON CERVICAL-CANCER, STAGE-IB BULKY

This study was carried out to determine the clinical and immune respon se of a stage IB voluminous uterine cervical cancer to thiophosphoric acid alkaloid derivates from Chelidoniium majus L. (Ukrain). The drugs were administered 10 mg intramuscularly every other day, for up to 10 injections. The two largest diameters and tumour volumes were measure d and laboratory and immunological tests were performed before and aft er Ukrain administration. The patients were then operated on with type III Piver's radical hysterectomy. Three out of nine eligible cases ha d partial responses while six cases remained stable. Decreased total B lymphocytes and suppressor T lymphocytes were observed as well as inc reased total numbers of T lymphocytes and helper T lymphocytes. There was no single case of clinical or haematological toxicity apart from m ild nausea. Two patients were treated with adjuvant radiotherapy due t o lymphatic involvement and all nine patients were still alive at leas t six months after follow-up.