EFFECT OF UKRAIN ON THE EFFICACY OF ANTIEPILEPTIC DRUGS AGAINST MAXIMAL ELECTROSHOCK-INDUCED SEIZURES IN MICE

Authors
JAGIELLOWOJTOWICZ E KLEINROK Z FELDO M CHODKOWSKA A NOWICKY JW
Citation
E. Jagiellowojtowicz et al., EFFECT OF UKRAIN ON THE EFFICACY OF ANTIEPILEPTIC DRUGS AGAINST MAXIMAL ELECTROSHOCK-INDUCED SEIZURES IN MICE, Drugs under experimental and clinical research, 18, 1992, pp. 107-109
Citations number
5
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Drugs under experimental and clinical research → ACNP
ISSN journal
03786501
Volume
18
Year of publication
1992
Supplement
S
Pages
107 - 109
Database
ISI
SICI code
0378-6501(1992)18:<107:EOUOTE>2.0.ZU;2-9
Abstract
It has been found that Ukrain, given intraperitoneally (i.p.), did not influence the threshold for maximal electroconvulsions in mice. Ukrai n in doses of 9.5 and 19 mg/kg significantly enhanced the protective e fficacy of valproate, decreasing the ED50 values. However, Ukrain had no effect on the protection provided by diazepam, carbamazepine, diphe nylhydantoin and phenobarbital. The combined treatment with Ukrain and anti-epileptic drugs did not cause any signs of toxicity.