REGULATION OF MYC - MAX COMPLEX-FORMATION AND ITS POTENTIAL ROLE IN CELL-PROLIFERATION

Authors
BLACKWOOD EM EISENMAN RN
Citation
Em. Blackwood et Rn. Eisenman, REGULATION OF MYC - MAX COMPLEX-FORMATION AND ITS POTENTIAL ROLE IN CELL-PROLIFERATION, Tohoku Journal of Experimental Medicine, 168(2), 1992, pp. 195-202
Citations number
28
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Tohoku Journal of Experimental Medicine → ACNP
ISSN journal
00408727
Volume
168
Issue
2
Year of publication
1992
Pages
195 - 202
Database
ISI
SICI code
0040-8727(1992)168:2<195:ROM-MC>2.0.ZU;2-K
Abstract
The myc family of proto-oncogenes encodes short-lived nuclear phosphop roteins (Myc) involved in the control of cell proliferation and differ entiation. Here we discuss the evidence for Myc's involvement in norma l and abnormal cell proliferation and review recent information on Max , a novel protein that forms a sequence-specific DNA-binding complex w ith Myc. The properties of the Myc: Max heterodimeric complex suggest a model for how Myc may function in the cell.