IMMUNOHISTOCHEMICAL IDENTIFICATION OF TRANSFORMING GROWTH-FACTOR-BETAAND ITS BINDING-PROTEIN IN HUMAN GASTROINTESTINAL CARCINOMA

Authors
MIZOI T OHTANI H MATSUNO S NAGURA H
Citation
T. Mizoi et al., IMMUNOHISTOCHEMICAL IDENTIFICATION OF TRANSFORMING GROWTH-FACTOR-BETAAND ITS BINDING-PROTEIN IN HUMAN GASTROINTESTINAL CARCINOMA, Tohoku Journal of Experimental Medicine, 168(2), 1992, pp. 271-273
Citations number
3
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Tohoku Journal of Experimental Medicine → ACNP
ISSN journal
00408727
Volume
168
Issue
2
Year of publication
1992
Pages
271 - 273
Database
ISI
SICI code
0040-8727(1992)168:2<271:IIOTG>2.0.ZU;2-P
Abstract
We attempted to clarify the tissue localization of TGF-beta and latent TGF-beta binding protein (LTBP) in human gastrointestinal carcinomas by immunohistochemistry. The immunoreactivity for TGF-beta was observe d in both carcinoma cells and stromal cells, particularly in diffuse-t ype gastric carcinoma. The immunoreactivity for LTBP was observed only in stromal cells. These results suggest that both carcinoma cells and stromal cells may produce TGF-beta, and that only stromal cells may p roduce LTBP in gastrointestinal carcinoma.