ANTITUMOR-ACTIVITY OF NEW ANTITUMOR SUBSTANCE, POLYOXOMOLYBDATE, AGAINST SEVERAL HUMAN CANCERS IN ATHYMIC NUDE-MICE

Antitumor polyoxomolybdates have been recognized in the course of stud y on the medical utilization of polyoxometalates, inorganic polymers o f metal oxide. [NH3Pri]6[Mo7O24].3H2O (PM-8) was found as a representa tive of antitumor polyoxomolybdates. The growth suppressions of PM-8 a gainst Co-4 human colon cancer xenografted under the subrenal capsule in cd-1 mice were equal or superior to that of 5-FU, MMC, ACNU, ADM an d CDDP. Potent antitumor activity of PM-8 is also established against MX-1 human breast and OAT human lung cancer xenografted in athymic nud e mice. Polyoxomolybdate is a new type of antitumor substance.