MITOCHONDRIAL-DNA AFFINITY OF SEVERAL JEWISH COMMUNITIES

The mitochondrial DNA (mtDNA) of 332 individuals from Israel, includin g 270 Jews (originating from 7 communities) and 62 Arabs, was analyzed . Each mtDNA haplotype was determined by the fragment patterns of rest riction enzymes HpaI, BamHI, HaeII, MspI (HpaII), and AvaII. The varia bility of the total sample and of each community was high. Of 40 diffe rent haplotypes, 20 were found more than once. Most haplotypes are typ ical of Caucasians, but African types were found among Ethiopian Jews and to a lesser extent among Arabs. The communities differed in their haplotypes: Chi-square tests among six communities showed significant differences for most pairwise comparisons and nonsignificant differenc es involving mainly the Moroccan Jews. In a genetic distance analysis only the Ethiopian Jews appeared to be distinguished from the other co mmunities. According to a G(ST) analysis, approximately 30% of the var iation among the mtDNA restriction maps is attributable to differences between communities.