ONE-POT DEPROTECTION AND COUPLING OF PEPTIDES BY THE FMOC STRATEGY

Authors
UEKI M NISHIGAKI N AOKI H TSURUSAKI T KATOH T
Citation
M. Ueki et al., ONE-POT DEPROTECTION AND COUPLING OF PEPTIDES BY THE FMOC STRATEGY, Chemistry Letters, (4), 1993, pp. 721-724
Citations number
14
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
4
Year of publication
1993
Pages
721 - 724
Database
ISI
SICI code
0366-7022(1993):4<721:ODACOP>2.0.ZU;2-R
Abstract
9-Fluorenylmethyloxycarbonyl (Fmoc) group can be quickly removed with tetrabutylammonium fluoride hydrate (TBAF.xH2O) in the presence of a l arge excess of phenylmethanethiol or 1-octanethiol. Subsequent oxidati on of the thiol with bis(1-methyl-1H-tetrazol-5-yl) disulfide simultan eously inactivated the TBAF and enabled one-pot peptide bond elongatio n by the Fmoc strategy.