SYNTHESIS AND HYDROLYSIS OF NEW ASPIRIN-DERIVED AND TRIFLUSAL-DERIVEDORTHO ESTERS AND ANHYDRIDES

Ten new 2-substituted 2-methyl-2-oxy-4H-1,3-benzodioxin-4-ones, 4a-i a nd 6, have been synthesized and their rate constants of pseudo-first-o rder non-enzymatic hydrolysis determined. One of the compounds, toxybe nzoyloxy)-2-methyl-4H-1,3-benzodioxin-4-one, 6, is a new anhydride of aspirin. The analogous triflusal derivative, 10, has also been synthes ized.