COMBINATION OF AMOROLFINE WITH VARIOUS ANTIFUNGAL DRUGS IN DERMATOPHYTOSIS

The fungistatic activity of ketoconazole, griseofulvin and terbinafine alone and in combination with amorolfine was tested in casitone agar. The fungistatic activity of all three against Trichophyton mentagroph ytes is slightly increased by the addition of amorolfine. In yeasts th e results are not so clear. The combinations of amorolfine with griseo fulvin, terbinafine, itraconazole and fluconazole were always more eff icient in a murine model of dermatophytosis than the monotherapy, thus a clear synergism between amorolfine and other antifungals was seen.