METRONIDAZOLE AND DRUG-RESISTANCE

In recent years, the basis of metronidazole resistance has been examin ed in anaerobic protozoa, such as Trichomonas and Giardia, as well as anaerobic bacteria, such as Bacteroides and Clostridium. In this revie w, Patricia Johnson looks at a variety of mechanisms that lead to redu ced susceptibility of these pathogens to the drug The frequent correla tion between metronidazole resistance and inefficient drug activation suggests that this is the level at which drug resistance operates.