F. Rossano et al., SOFT LASER (904 NM) IRRADIATION INDUCES CYTOKINE RELEASE BY HUMAN MONONUCLEAR-CELLS, International journal of immunopathology and pharmacology, 6(1), 1993, pp. 13-19
This study evaluates the effects of laser treatment (ASA AMICO S) on m
onocytes and lymphocytes in culture, irradiated at varying frequencies
and then incubated. The results obtained show that, at different freq
uencies, the laser beam can induce the release of some cytokines which
are capable of exerting modulatory effects on several biological func
tions. Interestingly, the release of IL-1alpha and TNFalpha is conside
rably higher than that obtained using Con A as a standard challenge. T
he notable increase in IL-1alpha release persists even 48h after the l
aser exposure, indicating that the laser does not interfere with lymph
ocyte activation induced by mitogens or antigens. Therefore, the fact
that: I) the release of cytokines occurs in laser-induced tissue repai
r and immune response by monocytes and II) the laser does not interfer
e with cytokine production by activated lymphocytes, is encouraging to
the therapeutic success of low-energy laser treatment.