MALIGNANT-MELANOMA OF THE CHOROID IN NEUROFIBROMATOSIS

A sixteen-year-old white girl with peripheral neurofibromatosis (NF1), who had been treated for a glioma of the optic nerves and chiasma dev eloped a choroidal mass in her only functional eye. After a transchoro idal biopsy, the pathologic examination disclosed a choroidal melanoma of epithelioid cell type, using morphological criteria as well as an immunohistochemical study. After treatment with a ruthenium plaque, th e tumor completely regressed over 4 months. According to the data of t he literature, neurofibromatosis seems to predispose to the developmen t of uveal melanomas.