A 38-day-old prematurely born infant developed rapidly progressive fac
ial cellulitis in association with ipsilateral submandibular lymphaden
opathy and pulmonary consolidation. Group B streptococci (GBS) were is
olated from blood, endotracheal, and lesion cultures. Prompt recogniti
on of GBS cellulitis-adenitis and institution of parenteral, synergist
ic antibiotic therapy are important.