THE ROLE OF LIPID-PEROXIDATION AND CALCIUM IN GALACTOSAMINE INDUCED TOXICITY IN THE RAT-LIVER

Authors
SECKIN S KOCAKTOKER N UYSAL M OZ B
Citation
S. Seckin et al., THE ROLE OF LIPID-PEROXIDATION AND CALCIUM IN GALACTOSAMINE INDUCED TOXICITY IN THE RAT-LIVER, Research communications in chemical pathology and pharmacology, 80(1), 1993, pp. 117-120
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Pathology
Journal title
Research communications in chemical pathology and pharmacology → ACNP
ISSN journal
00345164
Volume
80
Issue
1
Year of publication
1993
Pages
117 - 120
Database
ISI
SICI code
0034-5164(1993)80:1<117:TROLAC>2.0.ZU;2-K
Abstract
Liver homogenate and subcellular fractional levels of lipid peroxides, homogenate glutathione (GSH) and calcium contents and hepatic plasma membrane Ca2+-ATPase activity were determined in rats 12,18,24 and 48 hours after treatment with a single dose of 1 g/kg galactosamine. Lipi d peroxides and calcium levels in liver homogenate and subcellular fra ctions were found to increase, but hepatic GSH content and Ca2+-ATPase activity were observed to decrease reversibly.