Bt. Reece et al., AN INVITRO METHOD FOR SCREENING SUNSCREEN FORMULATIONS FOR SUN PROTECTION FACTOR USING A FULL-THICKNESS SKIN MODEL, Journal of the Society of Cosmetic Chemists, 43(6), 1992, pp. 307-312
With the aid of a full-thickness skin model, minimum sun protection fa
ctors (SPF) of various sunscreens were determined. Sunscreen efficacy
was determined by the release of interleukin IL-1alpha. The data show
that this in vitro model is capable of determining minimum SPFs of a f
ormula and may prove useful as a screen in the product development pro
cess.