LOW SUBSTITUTED N-OCTENYLSUCCINATE STARCH AS A DISSOLUTION RATE ENHANCER IN SOLID DOSAGE FORMS

The dissolution Tate enhancement properties of a low substituted N-oct enylsuccinate starch was evaluated in a solid dosage form, containing nifedipine as a poorly soluble drug. The use of the modified starch im proved dramatically the dissolution rate when prewetting was performed . The volume of wetting fluid had a critical influence on the dissolut ion rate and an optimum was reached when a 1% (w/w) dispersion was use d. The binding efficacy of the starch was poor. Low substituted N-octe nylsuccinate esters of waxy corn starch were shown to be a powerful di ssolution enhancer of drugs in solid dosage forms.