INFLUENCE OF LACTOBACILLUS-ACIDOPHILUS SOLCO ON IMMUNOLOGICAL PARAMETERS OF TOTALLY DECONTAMINATED MICE UNDER THE CONDITIONS OF GENERAL GERM-FREE ISOLATION

The possibility of stimulating the immunity of totally decontaminated mice, kept isolated under germ-free conditions, with the use of killed L. acidophilus Solco strains has been studied. As revealed in this st udy, the oral and intraperitoneal administration of strains O1 and O6 to mice leads to a significant increase in the content of immunoglobul in-synthesizing cells in the jejunal lamina propria of the animals. Th e oral administration of L. acidophilus Solco strain O6 and the intrap eritoneal injection of L. acidophilus Solco strain O1 have been found to lead to a significant rise in the level of luminol-dependent chemil uminescence of mouse peritoneal macrophages. The total decontamination of mice induces the development of secondary immunodeficiency which i nfluences the effectiveness of immunostimulating agents.