CICAPROST, A PROSTACYCLIN ANALOG, PROTECTS RENAL-FUNCTION IN UNINEPHRECTOMIZED DOGS IN THE ABSENCE OF CHANGES IN BLOOD-PRESSURE

Ten dogs presenting mild chronic renal failure and hypertension after 27 months of uninephrectomy, during which they received a high sodium and high protein diet, were divided in two groups (n = 5) and followed for 15 months. The same diet was maintained and one of the groups rec eived cicaprost treatment. The animals were periodically tested for bi ochemical and clinical parameters, and at months 0, 3, 6, and 15, glom erular filtration rate and renal plasma flow (RPF) were measured. Rena l biopsies were made after 6 months of follow-up. Control group showed a higher thickening of pre- and intraglomerular portions of arteriola r vessels and an enhancement of mesangial matrix when compared with th e treated group. Cicaprost also induced a significant elevation in RPF and a significant decrease in filtration fraction. All these findings suggest that cicaprost, an oral stable prostaglandin I2 analog, could have a protective renal effect in this experimental model.