Jc. Lopezgarcia et al., EFFECTS OF EXCITOTOXIC LESIONS OF THE NUCLEUS BASALIS MAGNOCELLULARISON CONDITIONED TASTE-AVERSION AND INHIBITORY AVOIDANCE IN THE RAT, Pharmacology, biochemistry and behavior, 45(1), 1993, pp. 147-152
The role of the nucleus basalis magnocellularis (NBM) in a variety of
learning tasks is well known. Lesions of this nucleus result in a redu
ction of cholinergic transmission throughout a vast portion of the cor
tex. Because cholinergic transmission in the insular cortex seems to b
e important for the acquisition of conditioned taste aversion, the aim
of the present work was to study the effects of bilateral chemically
induced lesions of the NBM on this conditioning, as correlated with so
me cholinergic markers in the insular cortex. The effect on inhibitory
avoidance was also studied. Lesions prevented the acquisition of the
aversion and disrupted retention of the task in previously trained ani
mals. Learning in the inhibitory avoidance paradigm was also notably a
ffected. Postlesion reductions of choline acetyltransferase and acetyl
cholinesterase activities and of K+-stimulated [H-3]acetylcholine rele
ase were found in the insular cortex. Further, in intact rats labeling
of NBM neurons was observed by retrograde tracing after injection of
Fluoro-Gold into the insular cortex. These findings indicate that the
NBM is involved in the neural integration of feeding behavior and that
its cholinergic projection to the insular cortex is one of the implic
ated neurotransmitter systems.