CHRONIC TREATMENT WITH VALPROATE DECREASES THE HYPOTHERMIC RESPONSE TO CLONIDINE

Authors
DILSAVER SC MINKUS D SWANN AC
Citation
Sc. Dilsaver et al., CHRONIC TREATMENT WITH VALPROATE DECREASES THE HYPOTHERMIC RESPONSE TO CLONIDINE, Pharmacology, biochemistry and behavior, 45(1), 1993, pp. 247-249
Citations number
24
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Pharmacology, biochemistry and behavior → ACNP
ISSN journal
00913057
Volume
45
Issue
1
Year of publication
1993
Pages
247 - 249
Database
ISI
SICI code
0091-3057(1993)45:1<247:CTWVDT>2.0.ZU;2-K
Abstract
Treatment with lithium (the prototype of an antimanic agent) attenuate s responsiveness to the alpha2-agonist clonidine in animal models. Val proate is now used to treat mania. The effect of treatment with this d rug on responses mediated by an alpha2-agonist have yet to be reported . The authors assessed the effect of a 14-day course of orally adminis tered valproate on the rat's hypothermic response to clonidine. Treatm ent with valproate decreased this response.