TOPICAL SUCRALFATE IN THE TREATMENT OF VAGINAL ULCERATION

Background: Non-neoplastic vaginal ulceration is at times recalcitrant to traditional methods of treatment. Sucralfate, a basic aluminum sal t of sucrose octasulfate, binds preferentially to ulcerated areas and promotes healing, an effect that does not appear to be acid-dependent. Case: Three cases of vaginal ulceration were treated with vaginal dou ches of sucralfate 10% suspension twice daily. One of the cases was du e to laser ablation for intraepithelial neoplasia, one was of uncertai n etiology, and one was caused by pessary use. Conclusion: After failu re of the initial therapeutic regimens, sucralfate treatment was succe ssful in all three cases and was well tolerated without side effects. Sucralfate vaginal douches should be considered for the treatment of n on-neoplastic vaginal ulcerations, particularly when other therapy has failed.