THE HISTORY OF THE PSYCHOPHARMACOLOGY OF SCHIZOPHRENIA

Objective: To review the historical development of the psychopharmacol ogical treatment of schizophrenia. Method: A chronological literature review of the clinical practices and theoretical models that have cont rolled drug treatment of schizophrenia al different times. Results: Ef fective treatment of schizophrenia was achieved only after the introdu ction of antipsychotic drugs, in the 1950s, and is still progressing. Conclusion: Close collaboration between basic neuroscience and careful and informed clinical practice are likely to lead to continued progre ss.