We performed a retrospective study on 45 patients admitted to the Rott
erdam Eye Hospital and the Ophthalmic Department of the Academic Medic
al Center in Amsterdam with pseudophakic endophthalmitis. Vitreous los
s during cataract extraction was associated with a significantly incre
ased risk of postoperative endophthalmitis when compared with uncompli
cated cataract extraction (p < 0.0001). The incidence of pseudophakic
endophthalmitis in diabetic patients was not significantly higher as c
ompared to non-diabetic patients. Vitrectomy in the treatment of posto
perative endophthalmitis did not improve the final visual acuity, prob
ably because of selection bias. Methicillin and cephazolin, used intra
vitreally against gram-positive organisms, failed to provide a good co
verage for endophthalmitis due to Staphylococcus epidermidis.